The effects of L-deprenyl on spatial
short term memory in young and aged dogs

Head E, Hartley J, Kameka AM, Mehta R,
Ivy GO, Ruehl WW, Milgram NW
University of Toronto,
Division of Life Sciences,
Scarborough, Ontario, Canada.
Prog Neuropsychopharmacol Biol Psychiatry 1996 Apr; 20(3):515-30


1. Young and aged dogs were tested on a spatial memory task using a delayed non matching to sample technique. Dogs were tested with 20, 70 and 110 second delay intervals. Animals were pretrained to a stable level of performance prior to treatment. 2. During treatment periods, dogs were orally administered a placebo or I-deprenyl in doses of 0.5 and 1.0 mg/kg in a repeated measures design. 3. Young dogs did not show any significant effects of I-deprenyl, however the sample size was limited. 4. L-deprenyl administration improved spatial memory in aged dogs. 5. The optimal dose or length of treatment time of I-deprenyl varied among individual dogs.

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