Selegiline in the treatment of Parkinson's disease:
its impact on orthostatic hypotension

by
Bhattacharya KF, Nouri S, Olanow CW,
Yahr MD, Kaufmann H.
Department of Neurology,
Mount Sinai School of Medicine,
10029, New York, NY, USA
Parkinsonism Relat Disord 2003 Mar;9(4):221-4


ABSTRACT

Less than a consensus exists as to whether chronic treatment with selegiline in combination with levodopa/carbidopa in patients with Parkinson's disease, is associated with more pronounced orthostatic hypotension than treatment with levodopa/carbidopa alone. To resolve this issue, we compared orthostatic tolerance and autonomic reflexes in 95 patients with Parkinson's disease treated chronically with either selegiline alone (n=10), levodopa/carbidopa alone (n=49) or both agents combined (n=36). Supine heart rate and blood pressure, autonomic cardiovascular reflexes and the frequency and magnitude of orthostatic hypotension were similar in all three treatment groups.

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