L-deprenyl: nitric oxide production
and dilation of cerebral blood vessels

by
Thomas T, McLendon C, Thomas G
Woodlands Medical and Research Center,
Oldsmar, FL 45677, USA.
Neuroreport 1998 Aug 3; 9(11):2595-600


ABSTRACT

The monoamine oxidase-B inhibitor L-deprenyl (Selegiline) is effective in treating Parkinson's disease and possibly Alzheimer's disease. The neuroprotective property of L-deprenyl may be unrelated to the inhibition of monoamine oxidase-B. Since nitric oxide (NO) modulates activities including cerebral blood flow and memory, we examined the effect of L-deprenyl on NO. L-Deprenyl induced rapid increases in NO production in brain tissue and cerebral vessels. Vasodilation was produced by endothelial NO-dependent as well as NO-independent mechanisms in cerebral vessels. The drug also protected the vascular endothelium from the toxic effects of amyloid-beta peptide. These novel actions of selegiline may protect neurons from ischemic or oxidative damage and suggest new therapeutic applications for L-deprenyl in vascular and neurodegenerative diseases.
Structure
Interactions
Parkinson's disease
Alzheimer's disease
Selegiline and cocaine
Selegiline and the DAT
Selegiline and nitric oxide
Selegiline and life-expectancy
Selegiline for longer-lived flies
Selegiline: product information
Selegiline as an immunostimulant
Selegiline for cocaine dependence
Selegiline, growth hormone and rats
Selegiline, NO and Alzheimer's disease


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