Effects of selegiline alone or
with donepezil on memory impairment in rats

Takahata K, Minami A, Kusumoto H, Shimazu S, Yoneda F.
Research Institute,
Fujimoto Pharmaceutical Corporation,
1-3-40 Nishiotsuka, Matsubara,
Osaka 580-0011, Japan
Eur J Pharmacol. 2005 Jul 30


Selegiline, a monoamine oxidase-B inhibitor, is reported to improve memory and learning in dementia of Alzheimer's type. However, only a few studies have reported its use in animal models. Here, we evaluated the effects of selegiline only or its combined use with donepezil, a selective acetylcholinesterase inhibitor on memory impairment, using a Morris water maze. Selegiline dose-dependently attenuated ethylcholine aziridinium ion-induced memory impairment. Co-administration of selegiline and donepezil, at doses that do not exert efficacy individually, significantly ameliorated scopolamine+p-chlorophenylalanine-induced memory deficits. These results suggest that selegiline improves memory impairment mediated by the cholinergic system, and provide evidence of the usefulness of co-treatment with selegiline and donepezil for treating spatial deficits in dementia.
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