Are metabolites of l-deprenyl (selegiline) useful or harmful? Indications from preclinical research
by
Yasar S, Goldberg JP, Goldberg SR
Department of Anesthesiology
and Critical Care Medicine,
Johns Hopkins University,
Medical School,
Baltimore, MD, USA.
J Neural Transm Suppl 1996; 48:61-7


ABSTRACT

A frequent topic of controversy has been whether metabolism of l-deprenyl (selegiline) to active metabolites is a detriment to clinical use. This paper reviews possible roles of the metabolites of l-deprenyl in producing unwanted adverse side effects or in augmenting or mediating its clinically useful actions. Levels of l-amphetamine and l-methamphetamine likely to be reached, even with excessive intake of l-deprenyl, would be unlikely to produce neurotoxicity and there is no preclinical or clinical evidence of abuse liability of l-deprenyl. In contrast, there is evidence that l-amphetamine and l-methamphetamine have some qualitatively different actions than their d-isomer counterparts on EEG and cognitive functioning which might result in beneficial clinical effects and complement beneficial clinical actions of l-deprenyl itself.

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